The phrase "are home in" refers to being comfortable or familiar with a particular thing, concept, or place. A few antonyms for this phrase are "out of place," "alien to," and "unfamiliar with." These words indicate a sense of unfamiliarity and disorientation, suggesting that someone may feel lost or uncomfortable in a particular situation. Other antonyms for "are home in" may include "unsure of," "hesitant about," and "doubtful of." Using these antonyms in place of the original phrase can help to convey a sense of uncertainty, discomfort, or unfamiliarity.