There are many synonyms for the term "physically run down," including exhausted, depleted, drained, fatigued, worn-out, weakened, and frazzled. These words describe a state of being tired, weak, or unable to function properly due to physical exhaustion or illness. Other words that can be used in this context include depleted, sapped, spent, enervated, and lethargic. It's important to note that these words can also be used metaphorically to describe someone's mental or emotional state, but their primary meaning is related to physical weakness or exhaustion. So if you're feeling physically run down, try using some of these synonyms to accurately convey how you're feeling.