The word "smallest" is an adjective that describes something as being of the least size or amount. Antonyms for smallest include biggest, largest, greatest, most substantial, and most significant. These words describe things that are of considerable size or amount, indicating that they are vast, prominent, weighty, or crucial. The antonyms of "smallests" can also indicate importance, value, or influence. Therefore, when speaking of the antonyms for "smallest," they are plentiful, and each can change the context of a sentence entirely. By using different antonyms for "smallest," a speaker or writer can convey different meanings with the same sentence.